کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4040019 1603264 2016 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Restore a 9 mm diameter osteochondral defect with gene enhanced tissue engineering followed mosaicplasty in a goat model
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی ارتوپدی، پزشکی ورزشی و توانبخشی
پیش نمایش صفحه اول مقاله
Restore a 9 mm diameter osteochondral defect with gene enhanced tissue engineering followed mosaicplasty in a goat model
چکیده انگلیسی

ObjectiveThe aim of this study was to evaluate the efficacy of gene enhanced tissue engineering followed mosaicplasty in a goat model.MethodsAn acute cylindrical defect 9 mm in diameter was created in the weight bearing area of the medial femoral condyle in a goat model. Thirty-six medial femoral condyles were divided into 6 groups using different proportion of gene enhanced tissue engineering and mosaicplasty to restore the defects. The specimen received gross and histology observation, which was evaluated by the histological grading scale of O'Driscoll, Keeley and Salter. Transmission electron microscope observation was also performed. Two factors analysis of variance and Student-Newman-Kewls test were used to compare the specimen.ResultsThe gross and histology observation revealed that each defects of six groups had different restoration. The scores of the reparative tissue of three groups with gene enhancement were significantly higher than those in other three groups without gene enhancement (p > 0.05).ConclusionGene enhanced tissue engineering followed mosaicplasty could restore a 9 mm diameter osteochondral defects in a goat model effectively. With the reduction of covering area of the graft, the advantages of the combined gene enhanced tissue engineering method can be better reflected.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Acta Orthopaedica et Traumatologica Turcica - Volume 50, Issue 4, August 2016, Pages 464–469
نویسندگان
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