کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4043057 | 1603505 | 2013 | 10 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: The Future Role of Mesenchymal Stem Cells in the Management of Shoulder Disorders The Future Role of Mesenchymal Stem Cells in the Management of Shoulder Disorders](/preview/png/4043057.png)
PurposeBiologics may help to optimize the healing environment after rotator cuff repair. Mesenchymal stem cells (MSCs) may have the potential to regenerate a physiological enthesis, thereby improving healing at the repair site after rotator cuff repair.MethodsThe PubMed database was searched in May 2013. Only in vivo and in vitro studies reporting on stem cell use in the rotator cuff of humans or animals were included. Exclusion criteria consisted of the following: Level V evidence, systematic reviews, and studies reporting preliminary results.ResultsThis query resulted in 141 citations. Of these, 90 were excluded based on the title of the study. A final group of 17 studies was included in this review (9 in vivo animal studies, 5 in vitro human studies, 1 in vitro animal study, 1 study reporting in vitro human and in vivo animal results, and 1 study reporting on clinical outcomes of human patients).ConclusionsThe current literature regarding therapeutic use of MSCs in shoulder surgery is limited. Although in vivo animal studies have shown some promising approaches to enhance tendon-to-bone healing, the use of MSCs for shoulder surgery should still be regarded as an experimental technique. Further basic and clinical research is needed until a procedure can be defined for the routine use of these cells in shoulder surgery.Level of EvidenceLevel IV, systematic review of Level III and IV, and animal laboratory studies.
Journal: Arthroscopy: The Journal of Arthroscopic & Related Surgery - Volume 29, Issue 10, October 2013, Pages 1702–1711