کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4054735 1265535 2013 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A Surgeon's guide to advances in the pharmacological management of acute Charcot neuroarthropathy
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی ارتوپدی، پزشکی ورزشی و توانبخشی
پیش نمایش صفحه اول مقاله
A Surgeon's guide to advances in the pharmacological management of acute Charcot neuroarthropathy
چکیده انگلیسی

Acute Charcot neuroarthropathy is a devastating condition and, its incidence is increasing. Currently, treatment consists of immobilisation and off-loading of the involved extremity. Outcomes are frequently poor and novel treatments are being sought urgently. This review aims to outline advances in the pharmacological treatment of this, condition.PubMed and the Cochrane Database of systematic reviews were searched. Relevant papers were cross referenced.Eleven original studies were identified. The limited data available suggest pamidronate, alendronate and calcitonin provide some clinical and biochemical improvements while zoledronic acid is deleterious and, increases off-loading times. However, the data is not robust enough to convincingly demonstrate clinically meaningful effects. The studies were predominantly low quality and heterogeneous. They differed markedly in study type, pharmacological agent used, dosing regimen, disease, aetiology/stage/location, concurrent off-loading regimen, outcomes and, follow-up. Few were rigorous in controlling for associated confounding variables and none investigated long term outcomes.The routine use of pharmacological treatment modalities for this condition is not recommended in the United States by the Food and Drug Administration or in the United Kingdom by the National Institute for Health and Clinical Excellence. Given the evidence available this is justified and further higher quality research is required.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Foot and Ankle Surgery - Volume 19, Issue 4, December 2013, Pages 212–217
نویسندگان
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