کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4055561 1603851 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Impaired synergic control of posture in Parkinson's patients without postural instability
ترجمه فارسی عنوان
اختلال در کنترل همرنگی وضعیت در بیماران پارکینسون بدون بی ثباتی موضعی
کلمات کلیدی
پوسیدگی، بیماری پارکینسون، همکاری، حالت عضلانی، تنظیمات هم افزایی پیش بینی شده
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی ارتوپدی، پزشکی ورزشی و توانبخشی
چکیده انگلیسی


• Patients with Parkinson's disease (PD, ≤stage-II) show reduced synergy indices during standing.
• PD patients show reduced anticipatory synergy adjustments.
• Analysis of multi-muscle synergies promises insights into postural control in PD.

BackgroundPostural instability is one of most disabling motor symptoms in Parkinson's disease. Indices of multi-muscle synergies are new measurements of movement and postural stability.ObjectivesMulti-muscle synergies stabilizing vertical posture were studied in Parkinson's disease patients without clinical symptoms of postural instability (Hoehn-Yahr ≤ II) and age-matched controls. We tested the hypothesis that both synergy indices during quiet standing and synergy adjustments to self-triggered postural perturbations would be reduced in patients.MethodsEleven Parkinson's disease patients and 11 controls performed whole-body tasks while standing. Surface electromyography was used to quantify synergy indices stabilizing center of pressure shifts in the anterior–posterior direction during a load-release task.ResultsParkinson's disease patients showed a significantly lower percentage of variance in the muscle activation space accounted for by the first four principal components, significantly reduced synergy indices during steady state, and significantly reduced anticipatory synergy adjustments (a drop in the synergy index prior to the self-triggered unloading).ConclusionsThe study demonstrates for the first time that impaired synergic control in Parkinson's disease can be quantified in postural tasks, even in patients without clinical manifestations of postural instability. Synergy measurements may provide a biomarker sensitive for early problems with postural stability in Parkinson's disease.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gait & Posture - Volume 44, February 2016, Pages 209–215
نویسندگان
, , , ,