کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4060320 1603988 2015 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Multipotent Adult Progenitor Cells from Bone Marrow Differentiate into Chondrocyte-Like Cells
ترجمه فارسی عنوان
سلولهای پیش ساز مولکولی بالغ از مغز استخوان، به سلول های شبیه به کندروسیته تقسیم می شوند
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی ارتوپدی، پزشکی ورزشی و توانبخشی
چکیده انگلیسی

Cartilage tissue engineering has great potential for treating chondral and osteochondral injuries. Efficient seed cells are the key to cartilage tissue engineering. Multipotent adult progenitor cells (MAPCs) have greater differentiation ability than other bone-marrow stem cells, and thus may be candidate seed cells. We attempted to differentiate MAPCs into chondrocyte-like cells to evaluate their suitability as seed cells for cartilage tissue engineering. Toluidine blue and Alcian blue staining suggested that glycosaminoglycan was expressed in differentiated cells. Immunofluorostaining indicated that differentiated human MAPCs (hMAPCs) expressed collagen II. Based on these results, we concluded that bone-marrow-derived hMAPCs could differentiate into chondrocyte-like cells in vitro.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Journal of Arthroplasty - Volume 30, Issue 7, July 2015, Pages 1273–1276
نویسندگان
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