کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4063003 1604089 2006 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Flexibility in Administration of Fondaparinux for Prevention of Symptomatic Venous Thromboembolism in Orthopaedic Surgery
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی ارتوپدی، پزشکی ورزشی و توانبخشی
پیش نمایش صفحه اول مقاله
Flexibility in Administration of Fondaparinux for Prevention of Symptomatic Venous Thromboembolism in Orthopaedic Surgery
چکیده انگلیسی

Venous thromboembolism (VTE) is a common complication of total joint arthroplasty. Fondaparinux VTE prophylaxis is currently begun 6 to 8 hours after surgery. Flexible dosing may reduce bleeding risk and allow easier use by starting the morning after surgery instead of staggered hours on the surgery day. This study examined flexible timing of the first dose of fondaparinux. Whether the first dose was administered 8 ± 2 hours after surgery or the morning after surgery, no significant difference was observed in incidence of symptomatic VTE (2.0% and 1.9%, respectively, P = .89). Major and minor bleeding events were similar between groups (1.2% and 0.7% [P = .19], and 1.4% and 2.0% [P = .31], respectively). Delaying initiation of fondaparinux prophylaxis provides an option after total joint arthroplasty with preserved efficacy and safety.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Journal of Arthroplasty - Volume 21, Issue 1, January 2006, Pages 36–45
نویسندگان
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