کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4063367 1604063 2008 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Decreased Venous Thromboembolism with Injectable Vs Oral Anticoagulation After Discharge for Major Orthopedic Surgery
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی ارتوپدی، پزشکی ورزشی و توانبخشی
پیش نمایش صفحه اول مقاله
Decreased Venous Thromboembolism with Injectable Vs Oral Anticoagulation After Discharge for Major Orthopedic Surgery
چکیده انگلیسی

The use of outpatient anticoagulation after major orthopedic surgery with oral or injectable anticoagulants is recommended by national guidelines. A retrospective analysis of medical and pharmacy claims data using the PharMetrics Patient-Centric Database Inc, Watertown, Mass, was conducted. After adjusting for covariates, patients receiving warfarin were approximately 30% more likely to experience a venous thromboembolism than those receiving an injectable anticoagulant (6.3% vs 4.8%; adjusted odds ratio, 1.3; 95% confidence interval, 1.1-1.5) by 30 days. The data at 90 days showed similar results. No significant differences in the incidence of major bleeding events between the cohorts were observed (incidence of major bleed <0.4%). These findings support the randomized controlled studies and expand the data to the real-world perspective. Clinicians should evaluate these data alongside the clinical trial data when selecting the safest and most effective prophylactic therapy for postdischarge anticoagulation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Journal of Arthroplasty - Volume 23, Issue 6, Supplement, September 2008, Pages 25–30
نویسندگان
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