Bone Invasion by Squamous Cell Carcinoma In Situ (Bowen's Disease) of the Finger During Treatment With Imiquimod 5% Cream: Case Report

Imiquimod 5% cream is known as an alternative treatment option for squamous cell carcinoma in situ (SCCIS), frequently termed Bowen's disease. Although imiquimod cream has been reported by many authors to treat SCCIS successfully, its efficacy and safety have not been fully established. The authors experienced a case in which ray amputation was necessary because of bone invasion by SCCIS in a finger being treated with imiquimod cream.