کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
407162 | 678130 | 2016 | 10 صفحه PDF | دانلود رایگان |
After several decades of study, the dynamics of synaptic plasticity in neurons still remains somewhat a mystery. By conducting a series of simulations on a simulated version of an in-vivo experiment on the rat dentate gyrus granule cell, using the Izhikevich spiking neuron model, we compare and contrast several potential synaptic plasticity rules׳ applicability to the same experiment. Our simulations reveal that spike timing dependent plasticity (STDP), a more recent theory of synaptic plasticity, is insufficient to replicate the heterosynaptic LTD shown in the experiment without including aspects of the significantly older Bienenstock–Cooper–Munro (BCM) theory. The STDP rule modified by including the history of postsynaptic spiking seems most likely to be an accurate candidate for reproducing the heterosynaptic plasticity dynamics.
Journal: Neurocomputing - Volume 175, Part A, 29 January 2016, Pages 300–309