Platelet-Rich Plasma in Treating Patellar Tendinopathy

Patellar tendinopathy (PT) is a common source of pain and dysfunction in both high-demand and recreational athletes. It can be a difficult condition to treat, and uniform consensus on the optimal treatment strategy is currently lacking. Accordingly, platelet-rich plasma (PRP) has emerged as a treatment option for tendinosis that may improve the healing process and speed recovery. It is becoming increasingly evident that PRP comprises a cocktail of growth factors and cellular components that synergize to contribute to its established anabolic effects. However, some PRP formulations also contain various inflammatory mediators that may adversely affect tendon healing. Although PRP is one of the most thoroughly studied biologics in orthopaedic applications, its role in the treatment of PT remains unclear. Though PRP may be considered for the treatment of recalcitrant PT, current consensus on its use is still inconclusive and outcomes are unpredictable. This evidence-based article summarizes the current understanding of PRP’s biological activity, clinical efficacy, and how it may be most effectively used to treat PT.