کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4080444 | 1267548 | 2010 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
(iii) Ewing's sarcoma of bone
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موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
ارتوپدی، پزشکی ورزشی و توانبخشی
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چکیده انگلیسی
Ewing's sarcoma is a primitive malignant bone tumour consisting of small, blue, round malignant cells that may show varying degrees of neural differentiation. It accounts for approximately 5% of all malignant bone tumours and arises most frequently in children or adolescents. Despite significant progress with the use of intensive multiagent chemotherapy and local control measures (survival rates have increased from 10-15% to 65-70% in the last 40 years), a significant proportion of patients still die of disease progression. Clinical and biological prognostic factors should be used to guide the therapeutic choices for each patient. The treatment of Ewing's sarcoma of bone is currently based on combined therapy with neoadjuvant chemotherapy, radiation therapy and surgical resection of the primary tumour. Survival in primary metastatic Ewing's sarcoma is poor (less than 30%) and new therapies are needed for these patients.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Orthopaedics and Trauma - Volume 24, Issue 5, October 2010, Pages 342-345
Journal: Orthopaedics and Trauma - Volume 24, Issue 5, October 2010, Pages 342-345
نویسندگان
Fabrice Fiorenza, Lee Jeys,