کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
408513 | 679031 | 2007 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: The significance of gap junction location in striatal fast spiking interneurons The significance of gap junction location in striatal fast spiking interneurons](/preview/png/408513.png)
Fast spiking (FS) interneurons in the striatum are hypothesised to control spike timing in the numerous medium spiny (MS) projection neurons by inhibiting or delaying firing in the MS neurons. The FS neurons are connected to each other through electrical gap junctions. This might synchronise the FS neurons, leading to increased influence on target neurons. Here, we explore the possible difference between proximal and distal gap junction locations. Somatic and distal dendritic gap junctions with equal effective coupling coefficient, as defined for steady-state somatic inputs, showed significantly different effective coupling coefficient with transient inputs. However, the ability to synchronise spiking in pairwise coupled FS neurons, which received synaptic inputs as during striatal up-state periods, was as effective with distal gap junctions as with proximal ones. Proximal gap junctions, however, caused synchronisation within a more precise time window.
Journal: Neurocomputing - Volume 70, Issues 10–12, June 2007, Pages 1887–1891