کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4096222 1268555 2015 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Pathologic sternal involvement is a potential risk factor for severe sagittal plane deformity in multiple myeloma with concomitant thoracic fractures
ترجمه فارسی عنوان
دخالت سکته مغزی آسیب شناسی یک عامل خطر بالقوه برای انحراف شکل هواپیما شدید سائیداتال در مولتیپل میلوما همراه با شکستگی های جانبی سینه است
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی ارتوپدی، پزشکی ورزشی و توانبخشی
چکیده انگلیسی

Background ContextSkeletal involvement is observed in almost 80% of patients presenting with symptomatic multiple myeloma (MM). The vertebral column is the most frequently affected site by myeloma-induced osteoporosis, osteolysis, and compression fractures. Multiple pathologic compression fractures can lead to significant spinal deformity, which is often considered for complex reconstruction because of the poor quality of life for the affected patients.PurposeThis study aimed to compare the clinical and radiological outcomes of two groups of MM patients; the first group had thoracic spine fractures and a concomitant pathologic sternal fracture (SF), and the second group had thoracic fractures but no sternal fracture (NSF).Study DesignThis was a cross-sectional study.Patient SampleThe sample comprised 98 consecutive patients (n=98) with symptomatic MM and concomitant pathologic thoracic spine fractures over a 3-year period at a national tertiary referral center for the management of MM with spinal involvement.Outcome MeasuresClinical outcome measures used included European Quality of Life-5 Dimensions (EQ-5D), Oswestry Disability Index (ODI), and visual analogue scale (VAS) pain score.MethodsAll consecutive patients with MM were enrolled. The cohort was split into two patient groups: patients with SFs (SF group) and patients without sternal fractures (NSF group). Clinical, serologic, and pathologic variables, radiological findings, treatment strategies, and outcome measures were collected.ResultsThe SF group was younger (58±13 years vs. 66±11 years [p=.008]) when compared with the NSF group. The SF group presented with a greater thoracic kyphosis (73°±18° vs. 53°±17.5° [p=.005]), similar VAS pain scores (50.6±22.1 vs. 54.4±22.5 [p>.05]), but poorer EQ-5D (0.24±0.13 vs. 0.48±0.23 [p<.001]) score and ODI (60.6±10.3 vs. 48.2±17.8 [p=.013]) when compared with the NSF group.ConclusionsPathologic SF in an MM patient with thoracic compression fractures is a potential risk factor for the development of a severe thoracic kyphotic deformity and sagittal malalignment. This has been demonstrated in this study to be associated with a very poor health-related quality of life. A greater awareness of sternal myeloma disease is needed at presentation (the time of the primary survey) so that SFs can be potentially avoided, thereby preventing progression to a severe kyphotic deformity.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Spine Journal - Volume 15, Issue 12, 1 December 2015, Pages 2503–2508
نویسندگان
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