کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4096457 1268562 2016 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Longitudinal extension of myelomalacia by intramedullary and subdural hemorrhage in a canine model of spinal cord injury
ترجمه فارسی عنوان
گسترش طولی مایولومالاسیا به وسیله خونریزی داخل جمجمه و زیردوره در یک مدل سگ آسیب نخاعی
کلمات کلیدی
صعودی، کانال مرکزی، نزولی اکستروژن دیسک بین مهره ای، فشار اینترامودولار، ترومای نخاعی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی ارتوپدی، پزشکی ورزشی و توانبخشی
چکیده انگلیسی

Background ContextIn canine intervertebral disc (IVD) extrusion, a spontaneous animal model of spinal cord injury, hemorrhage is a consistent finding. In rodent models, hemorrhage might be involved in secondary tissue destruction by biochemical mechanisms.PurposeThis study aimed to investigate a causal association between the extents of intramedullary, subdural and epidural hemorrhage and the severity of spinal cord damage following IVD extrusion in dogs.Study Design/SettingA retrospective study using histologic spinal cord sections from 83 dogs euthanized following IVD extrusion was carried out.MethodsThe degree of hemorrhage (intramedullary, subdural, epidural), the degree of spinal cord damage in the epicenter (white and gray matter), and the longitudinal extent of myelomalacia were graded. Associations between the extent of hemorrhage and the degree of spinal cord damage were evaluated statistically.ResultsIntramedullary and subdural hemorrhages were significantly associated with the degree of white (p<.001/ p=.004) and gray (both p<.001) matter damage, and with the longitudinal extension of myelomalacia (p<.001/p=.005). Intriguingly, accumulation of hemorrhagic cord debris inside or dorsal to a distended and ruptured central canal in segments distant to the epicenter of the lesion was observed exhibiting a wave-like pattern on longitudinal assessment. The occurrence of this debris accumulation was associated with high degrees of tissue destruction (all p<.001).ConclusionsTissue liquefaction and increased intramedullary pressure associated with hemorrhage are involved in the progression of spinal cord destruction in a canine model of spinal cord injury and ascending or descending myelomalacia. Functional and dynamic studies are needed to investigate this concept further.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Spine Journal - Volume 16, Issue 1, 1 January 2016, Pages 82–90
نویسندگان
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