کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4096947 1268573 2014 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Long-term clinical outcome of sacral chondrosarcoma treated by total en bloc sacrectomy and reconstruction of lumbosacral and pelvic ring using intraoperative extracorporeal irradiated autologous tumor-bearing sacrum: a case report with 10 years follow-up
ترجمه فارسی عنوان
نتایج بالینی طولانی مدت کندروسارکومای ساکرال تحت درمان با سرکروکتومی کل ان بلوک و بازسازی لومبوساکرال و حلقه لگن با استفاده از سکته مغزی با تومورهای اتولوگ ادراک شده خارج شده درون مفصلی: گزارش مورد با پیگیری 10 ساله
کلمات کلیدی
کندروسارکوم، کل اکسیژن داخل سلول، اشعه ماوراء الطبیعه درون تراپی، نتیجه بالینی بلند مدت، بازسازی لومبوساکرال و حلقه لگن، بازسازی در استخوان زنده
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی ارتوپدی، پزشکی ورزشی و توانبخشی
چکیده انگلیسی

Background contextPrimary malignant tumors of the sacrum are rare. Chondrosarcoma is one of the common malignant tumors arising from the sacrum. Chondrosarcoma is often invasive, and there is a high propensity for local recurrence. Surgical resection is often the only effective treatment; however, the treatment of malignant sacral tumors can be challenging, both because of the anatomy of the spinopelvic complex and the frequently large tumor size.PurposeWe report a case of sacral chondrosarcoma that was successfully treated by total en bloc sacrectomy and reconstruction of the lumbosacral and pelvic ring using intraoperative extracorporeal irradiated autologous tumor-bearing sacrum.Study designA case report with 10 years follow-up.MethodsA 51-year-old man presented with right lower leg pain. Plain radiographs and computed tomography (CT) showed an osteolytic lesion at the sacrum that extended to the sacroiliac joint. Magnetic resonance imaging demonstrated that the tumor mass was localized from S1 to S2 with an epidural lesion at L5–S1 disc level. Histopathologic evaluation by open biopsy revealed that the lesion was chondrosarcoma. Total en bloc sacrectomy of the tumor-bearing sacrum was performed. The removed tumor-bearing sacrum was extracorporeally irradiated at 200 Gy during the operation and returned to the original position as a bone graft and fixed with instruments thereafter.ResultsWe needed two revision surgeries during the first 3 years because of the implant failures; however, 10 years after the initial surgery, CT revealed that the irradiated sacrum had remodeled into living bone and integrated with surrounding iliac bone without radiological evidence of tumor recurrence. The patient ambulates without any support and there was no clinical and radiological evidence of tumor recurrence.ConclusionsThe advantages of our method include the availability of high dose of radiation because of extracorporeal irradiation, excellent fit between graft and host bone, reduction of the dead space, no immunological rejection, no need for a bone bank, availability of the sacrum not only for the augmentation of the large defect but also for the scaffold for the other bone grafts. Our report is of only one case; however, we consider that it could be one option for the treatment of sacral malignant bone tumors, such as chondrosarcoma.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Spine Journal - Volume 14, Issue 5, 1 May 2014, Pages e1–e8
نویسندگان
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