کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4106425 1605388 2012 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Head and neck cancer: genetic polymorphisms and folate metabolism
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری های گوش و جراحی پلاستیک صورت
پیش نمایش صفحه اول مقاله
Head and neck cancer: genetic polymorphisms and folate metabolism
چکیده انگلیسی

Epidemiological evidence suggests that genetic variants encoding enzymes involved in folate metabolism may modulate HNSCC risk by altering DNA methylation synthesis and genomic estability.AimA review of the literature on genetic polymorphisms involved in folate metabolism and risk of head and neck cancer was carried out.Methodology: An electronic search was made on the Medline database to select papers on head and neck cancer and polymorphisms involved in folate metabolism.ResultsThe association between MTHFR C677T polymorphism and the risk of this tumor type was evaluated in nine studies; there was an association with this disease in three papers. The MTR A2756G and MTRR A66G and RFC1 A80G polymorphisms were also associated with increased risk for HNSCC. MTHFD1 G1958A polymorphism was not associated with increased risk of this disease; the evaluation results of the MTHFR A1298C polymorphism in this neoplasm were contradictory. Other polymorphisms involved in folate metabolism were not studied for this neoplasm.ConclusionWe conclude that polymorphisms involved in folate metabolism may modulate the risk of head and neck cancer, however, these results need to be demonstrated in different populations.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brazilian Journal of Otorhinolaryngology - Volume 78, Issue 1, January–February 2012, Pages 132–139
نویسندگان
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