کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
410718 679160 2011 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
PITAGORAS-PSP: Including domain knowledge in a multi-objective approach for protein structure prediction
موضوعات مرتبط
مهندسی و علوم پایه مهندسی کامپیوتر هوش مصنوعی
پیش نمایش صفحه اول مقاله
PITAGORAS-PSP: Including domain knowledge in a multi-objective approach for protein structure prediction
چکیده انگلیسی

Whenever evolutionary algorithms are used to solve certain classes of problems such as those that present a huge search space, the incorporation of problem-specific knowledge is required to achieve adequate levels of performance. In this paper, we propose a multi-objective optimization-based procedure that includes such a domain-specific knowledge to cope with a difficult problem, the protein structure prediction (PSP). This problem is considered to be an open problem as there is no recognized “best” procedure to find solutions. It presents a vast search space and the analysis of each protein conformation requires significant amount of computing time. In our procedure, we provide a reduction of the search space by using the dependent rotamer library and include new heuristics to improve a multi-objective approach to PSP based on the PAES algorithm. As it is shown in the paper, by using benchmark proteins from the CASP8 set, this hybrid PSP procedure provides competitive results when it is compared with some of the better proposals appeared up to now.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurocomputing - Volume 74, Issue 16, September 2011, Pages 2675–2682
نویسندگان
, , ,