کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4115042 1606081 2008 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Changes in serum levels of IGF-1 and in growth following adenotonsillectomy in children
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری های گوش و جراحی پلاستیک صورت
پیش نمایش صفحه اول مقاله
Changes in serum levels of IGF-1 and in growth following adenotonsillectomy in children
چکیده انگلیسی

SummaryObjectiveAdenotonsillar hypertrophy can cause upper airway obstruction and may be associated with growth delay in children. The objective of this study was to evaluate the long-term effects of adenotonsillectomy on height, weight, and body mass index (BMI) in children with sleep-disordered breathing (SDB).MethodsFifty-two children (mean age 6.2 ± 2.3 years) clinically diagnosed with SDB were enrolled. Children were diagnosed and scheduled for adenotonsillectomy (T&A) based on their responses to the validated, 22-item Sleep Related Breathing Disorder (SRDB) scale and a physical examination that showed adenotonsillar hypertrophy. Weight, height, and BMI were evaluated before and 5 years after T&A. Serum levels of insulin-like growth factor-1 (IGF-1) were measured before and 1 month after T&A.ResultsSerum levels of IGF-1 were significantly higher at 1 month after T&A compared to before T&A (p < 0.001). Thirty children (58%) returned for follow-up testing 5 years later. Their Z scores (standard deviation scores) for weight, height, and BMI of 30 children were significantly higher 5 years after T&A compared to before T&A (p < 0.01).ConclusionChildren with SDB who undergo adenotonsillectomy show significant, long-term increases in weight, height and BMI, as well as a significant increase in serum levels of IGF-1.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pediatric Otorhinolaryngology - Volume 72, Issue 7, July 2008, Pages 1065–1069
نویسندگان
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