Nasal mucosa ulceration and septal perforation as initial presentation of a patient with probable Behcet's disease

Behcet's disease is a vasculitis that affects multiple systems in the body, classically oral and genital mucosa. Nasal mucosa involvement is a rare manifestation of the disease, reported in only a handful of patients. We present an HLA-B51 positive, suspected Behcet's patient with predominantly nasal manifestations including epistaxis, nasal mucosa ulceration and septal perforation. Her nasal symptoms have improved since being started on a daily regimen of colchicine. We believe this case supports the wide clinical heterogeneity of the disorder, and serves as a reminder to consider Behcet's disease when a patient presents with an atypical head and neck manifestation.