Comparison of clarity of nucleocytoplasmic differentiation of oral tissues processed by microwave and conventional methods

The microwave-assisted tissue processing is believed to have brought a revolutionary improvement in histopathology. The technique shortens the tissue processing time from hours to minutes. The technique is responsive to the patient and physician needs, improves the use of reagents while reducing or eliminating their toxicity, creates a personnel-friendly workflow, and places the laboratory in a better position to meet the demands of the rapidly expanding field of molecular medicine. This study was conducted to determine the efficacy of microwave tissue processing method for orofacial biopsy specimens by comparing 5 different protocols of microwave histoprocessing with the conventional method, based on the clarity of nucleocytoplasmic differentiation of tissues processed by each method. The current study demonstrated that different protocols of microwave histoprocessing can be achieved without a demonstrable decrease in section quality or interpretation.