کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4135466 | 1271498 | 2006 | 13 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Splenic small B-cell lymphoma with IGH/BCL3 translocation Splenic small B-cell lymphoma with IGH/BCL3 translocation](/preview/png/4135466.png)
SummaryIsolated chromosomal translocations are important defining features of many non-Hodgkin lymphomas, especially of B-cell type. In contrast to some other translocations, the significance of IGH/BCL3 translocations is not well defined. Although often considered a feature of the ill-defined entity atypical chronic lymphocytic leukemia, very few cases are reported in which involvement of BCL3 and the precise B-cell neoplasm are both well documented. For this reason, we report a splenic-based CD5−, CD10−, CD43−, CD23−, CD103−, FMC7+, CD25+ small B-cell lymphoma associated with epithelioid histiocyte clusters and a t(14;19)(q32;q13) representing an IGH/BCL3 translocation based on classical cytogenetic studies, chromosomal painting, and fluorescence in situ hybridization studies. The previously reported neoplasms with t(14;19)(q32;q13) or IGH/BCL3 translocations are also reviewed. The present case did not fall into any of the classic B-cell lymphoma categories and clearly did not represent chronic lymphocytic leukemia/small lymphocytic lymphoma. This case suggests that the IGH/BCL3 translocation may help to define a new clinicopathologic entity.
Journal: Human Pathology - Volume 37, Issue 2, February 2006, Pages 218–230