Un nouvel éclairage physiopathologique de la modulation de la réponse immune par les lactobacilles

Studies on probiotics had found a benefit in their use. That was attributed to a barrier effect at the intestinal mucosa. We tried a new immunephysiological explanation supported by murine works and in humans. Immune modulation by probiotic bacteria and induce IL10 producing regulatory T cells. Receptors DCSIGN and Toll dendrites cells interfere in the copresentation of antigens and generate an immune response modulation by regulatory T cells and their inhibitory cytokines TGFβ, IL10.