Serum levels of 25(OH) vitamin D and immunoglobulin E in infants with bronchiolitis

Vitamin D status has a great effect on respiratory health throughout the lifespan.The aim of this studyThe aim of this study was to estimate and find the relationship between both 25(OH) vitamin D and immunoglobulin E serum levels and bronchiolitis in infancy.MethodsWe quantified serum 25(OH) D and serum immunoglobulin E using (ELISA) in 50 infants with bronchiolitis and 31 healthy controls of matched age and sex.ResultsThe mean serum 25(OH) vitamin D was significantly lower in cases than in controls; it was (12.3 ± 3.9 & 26.2 ± 10.0 ng/ml, respectively with p = 0.003). The mean serum IgE was significantly higher in cases than in controls; It was (170 ± 66 & 43.8 ± 14.2 IU/ml, respectively and p = 0.01). Serum IgE showed a non-significant negative correlation with serum 25(OH) vitamin D (r = −0.141, p = >0.05).ConclusionsSerum 25(OH) vitamin D was found in decreased quantities in infants with bronchiolitis and it was negatively correlated with serum IgE, suggesting that vitamin D may play a role in the pathogenesis of bronchiolitis.