Successful treatment of severe gastrointestinal manifestations of Henoch–Schonlein Purpura and factor XIII deficiency using cryoprecipitate transfusion

Henoch–Schonlein Purpura (HSP) might present with severe gastrointestinal (GI) involvement. Herein, we report 3 cases of HSP with severe GI manifestations in the form of hematemesis, melena, pancreatitis, and erosive gastritis. Different treatment modalities were not successful. Low factor XIII levels were found in all patients and Cryoprecipitate transfusion resulted in significant immediate clinical improvement.