کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4155055 | 1273735 | 2015 | 5 صفحه PDF | دانلود رایگان |
BackgroundThe purpose is to delineate the clinical and pathological characteristics of rare primary malignant pulmonary tumors in children.MethodsUtilizing the National Cancer Data Base (NCDB), we analyzed all children (≤ 18 years) with a primary malignant pulmonary tumor from 1998 to 2011 to identify factors associated with better survival.ResultsOf 211 children identified, the most common histology was carcinoid tumor (n = 133, 63%) followed by mucoepidermoid carcinoma (MEC) (n = 37, 18%), squamous cell carcinoma (SCC) (n = 19, 9%), adenocarcinoma (n = 16, 8%), bronchoalveolar carcinoma (BAC) (n = 4, 2%), and small cell carcinoma (SCLC) (n = 2, < 1%). Factors that significantly affected survival include histology, race, tumor size, lymph node status, and extent of surgery. Patients with MEC and carcinoid tumors had a better overall survival compared to patients with other histologies (p < 0.0001). The 5-year overall survival for MEC and carcinoid tumors was 100% and 95% (95% CI 87–98), respectively, versus 50% (95%CI 1–91) for BAC, 28% (95%CI 9–52) for SCC, and 26% (95%CI 5–55) for adenocarcinoma.ConclusionThe majority of pediatric patients with a primary malignant pulmonary tumor present with carcinoid tumor or MEC and have an excellent prognosis. Lung cancers which are common in adults, but rare in children, have a worse prognosis.
Journal: Journal of Pediatric Surgery - Volume 50, Issue 6, June 2015, Pages 1004–1008