کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4155603 1273751 2014 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Analysis of recurrence risks for sacrococcygeal teratoma in children
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پریناتولوژی (پزشکی مادر و جنین)، طب اطفال و بهداشت کودک
پیش نمایش صفحه اول مقاله
Analysis of recurrence risks for sacrococcygeal teratoma in children
چکیده انگلیسی

Background/PurposeThe purpose of this study was to investigate effects of risk factors on recurrence of sacrococcygeal teratoma (SCT).MethodsA retrospective review was conducted of 107 SCTs treated between January 2003 and December 2012 in our center. Risk factors were identified by univariate and multivariate analysis.ResultsSixteen children had recurrence of SCT a median interval of 16.25 months after primary surgery. 15.6% tumors recurrence were Altman type I, 10.5% type II, 10.0% type III, and 31.3% type IV. The recurrence of mature teratoma was observed in 8 patients, immature in 2, malignant in 5. More than half of the recurrences showed a shift towards histological immaturity or malignancy, compared with the primary tumor pathology. Risk factors for recurrence were spillage of tumor parenchyma during operation (P = 0.028), incomplete resection (p = 0.000), and primary immature (P = 0.029) and malignant histology (P = 0.026). Size, Altman classification, and age were not risk factors for recurrence. There was a statistically significant difference in OS between patients who developed relapse (64.8%) and those who did not (95.0%) (P = 0.0002).ConclusionsTumor recurrence affected the outcome of children with SCT. Risk factors were tumor spillage, immature and malignant histology, or incomplete resection. Regular follow-up after surgery is mandatory to find tumor relapse earlier and to improve the outcome.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pediatric Surgery - Volume 49, Issue 12, December 2014, Pages 1839–1842
نویسندگان
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