کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4160000 1273836 2007 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Classification of neuroblastomas based on an analysis of the expression of genes related to prognosis
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پریناتولوژی (پزشکی مادر و جنین)، طب اطفال و بهداشت کودک
پیش نمایش صفحه اول مقاله
Classification of neuroblastomas based on an analysis of the expression of genes related to prognosis
چکیده انگلیسی

PurposeTo select the optimal treatment according to the grade of malignancy of neuroblastoma (NB), it is essential to accurately and rapidly identify genetic abnormalities associated with the prognosis. We have identified BIN1 and neuronatin β as the novel prognosis-related genes for NBs. This study aims to assess the correlation between the combination of the expression level of prognosis-related genes and the outcome of NB.MethodsIn 44 NB samples, the expression levels of TrkA, BIN1, and neuronatin β were determined using quantitative reverse transcriptase–polymerase chain reaction; furthermore, the correlation between the expression of these genes' expression levels and the clinical progression of NB were assessed.ResultsIt was possible to classify 44 NBs into 4 groups regarding the grade of malignancy of NB. These 4 groups were all significantly associated with the clinical stages international NB staging system as well as the outcomes of the patients (P < .001, according to the trend test by Kruskal-Wallis exact test).ConclusionThe combination of the expression levels of these genes using quantitative reverse transcriptase–polymerase chain reaction is indicated as the effective method to quickly and accurately evaluate the grade of malignancy of NBs.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pediatric Surgery - Volume 42, Issue 12, December 2007, Pages 2046–2049
نویسندگان
, , , , , ,