Keywords: ALS; amyotrophic lateral sclerosis; NGF; nerve growth factor; NSC; neural stem cell; MAP 2; microtubule-associated protein 2; TrkA; tropomyosin receptor kinase; Amyotrophic lateral sclerosis; Cell therapy; SOD1 mice; Nerve growth factor;
مقالات ISI (ترجمه نشده)
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Keywords: Neurotrophin 3 (NT3); TrkA; RAS/MAPK; PI3K; Axon growth;
Keywords: TrkA; TrkB; Antagonist; Fragment-based QSAR; 2-Oxindole;
Keywords: Cyr61; cysteine-rich protein 61; RA; rheumatoid arthritis; IL-17; interleukin-17; ECM; extracellular matrix; CTGF; connective tissue growth factor; IGFBP; insulin-like growth factor binding protein domain; VWC; von Willebrand type C repeat; TSP-1; thrombo
Keywords: AML; acute myeloid leukemia; APL; acute promyelocytic leukemia; ATRA; all-trans retinoic acid; BHA; butylated hydroxyanisole; C/EBP; CCAAT/enhancer binding proteins; CREB; cyclic AMP response element-binding proteins; CSF; cerebrospinal fluid; DUOX; dual
Keywords: AA; ascorbic acid; AAV; adeno-associated viral; ACh; acetylcholine; AD; Alzheimer's disease; ANOVA; analysis of variance; BF; basal forebrain; ChAT; choline acetyltransferase; CHT; choline transporter; DA; dopamine; DAB; 3-3â²-diaminobenzidine; dSAT; d
Keywords: Rat; Gingivomucosa; Pulp; TrkA; IB4-binding;
Identification of a novel mutation of the NTRK1 gene in patients with congenital insensitivity to pain with anhidrosis (CIPA)
Keywords: ALP; alkaline phosphatase; CIPA; congenital insensitivity to pain with anhidrosis; HSAN IV; autonomic neuropathy type IV; NGF; nerve growth factor; NTRK1; brachydactyly; TrkA; tyrosine kinase receptor A; β-CTX; βcross-linked C-telopeptide of type 1 coll
Pharmacological inhibition of Receptor Protein Tyrosine Phosphatase β/ζ (PTPRZ1) modulates behavioral responses to ethanol
Keywords: ALK; TrkA; Alcohol use disorder; Binge-drinking; Pleiotrophin; Midkine;
Neuritogenic effect of sea cucumber glucocerebrosides on NGF-induced PC12 cells via activation of the TrkA/CREB/BDNF signalling pathway
Keywords: PC12 cells; Sea cucumber cerebrosides; Neuritogenic effect; TrkA; CREB; BDNF;
Role of TrkA signalling and mast cells in the initiation of osteoarthritis pain in the monoiodoacetate model
Keywords: Prostaglandin D2; NGF; TrkA; Osteoarthritis; Mast cells;
The Changing Sensory and Sympathetic Innervation of the Young, Adult and Aging Mouse Femur
Keywords: CGRP; calcitonin gene-related peptide; DAPI; 4â²,6-diamidino-2-phenylindole; EDTA; ethylenediaminetetraacetic acid; NGF; nerve growth factor; TH; tyrosine hydroxylase; TrkA; tropomyosin-related kinase receptor A; skeletal; nociceptors; pediatric; genetic
Emerging therapies for atopic dermatitis: TRPV1 antagonists
Keywords: atopic dermatitis; clinical trials; pruritus; skin barrier; transient receptor potential; TRPV1/substance P inhibitors; AD; atopic dermatitis; NK-1R; neurokinin-1 receptor; SP; substance P; TrkA; tropomyosin receptor kinase A; TRP; transient receptor pote
Nogo-A interacts with TrkA to alter nerve growth factor signaling in Nogo-A-overexpressing PC12 cells
Keywords: NGF; nerve growth factor; nSMase; neutral sphingomyelinase; p75NTR; p75 neurotrophin receptor; p75NTR ICD; intracellular domain fragment of p75NTR; PKC; protein kinase C; PMA; phorbol 12-myristate 13-acetate; PY; phosphotyrosine; RIP; regulated intramembr
Ligand-based computer aided drug design reveals new tropomycin receptor kinase a (TrkA) inhibitors
Keywords: GFA; genetic function algorithm; Hbic; hydrophobic; MLR; multiple linear regression; TrkA; Tropomycin kinase A; NCI; National Cancer Institute; ROC; receiver operating characteristic; TrkA; Tyrosine kinase inhibitor; Discovery studio; QSAR; Pharmacophore;
The histology, physiology, neurochemistry and circuitry of the substantia gelatinosa Rolandi (lamina II) in mammalian spinal cord
Keywords: [Ca2+]i; intracellular Ca2+ concentration; 5-HT; serotonin; Ach; acetylcholine; AMP; adenosine monophosphate; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; AMPAR; AMPA receptor; BDNF; brain-derived neurotrophic factor; CCK; cholecystokinin;
The juxtamembrane region of TrkA kinase is critical for inhibitor selectivity
Keywords: TrkA; Juxtamembrane region; Allosteric inhibitor; Crystal structure; Tyrosine kinase inhibitor;
Design, synthesis and SAR of substituted indoles as selective TrkA inhibitors
Keywords: TrkA; Pain; Indoles;
Small molecule antidepressant amitriptyline protects hypoxia/reoxygenation-induced cardiomyocyte apoptosis through TrkA signaling pathway
Keywords: Cardiomyocyte; Hypoxia; Reoxygenation; Apoptosis; Amitriptyline; TrkA;
NGF protects endothelial cells from indomethacin-induced injury through activation of mitochondria and upregulation of IGF-1
Keywords: Nerve growth factor; TrkA; Endothelial cells; Mitochondrial membrane potential; Angiogenesis; Indomethacin;
Trigonelline promotes auditory function through nerve growth factor signaling on diabetic animal models
Keywords: Auditory brainstem response (ABR); Transient evoked otoacoustic emission (TEOAE); Hair cells; Molecular docking; db/db mice; Zebrafish; ABR; auditory brainstem response; AX; alloxan monohydrate; db/db; homozygous for leptin receptor-deficient; dbh; hetero
The role of Celsr3 in the development of central somatosensory projections from dorsal root ganglia
Keywords: CGRP; calcitonin gene-related peptide; ChAT; choline acetyltransferase; CNS; central nervous system; DRG; dorsal root ganglion; PBS; phosphate-buffered saline; PV; Parvalbumin; TrkA; neurotrophic tyrosine kinase receptor1; TrkB; neurotrophic tyrosine kina
Neurodegenerative effects of azithromycin in differentiated PC12 cells
Keywords: Azithromycin (PubChem CID: 447043); Azithromycin; Cell death; Autophagy; Akt; TrkA; PC12 cells;
Nerve growth factor derivative NGF61/100 promotes outgrowth of primary sensory neurons with reduced signs of nociceptive sensitization
Keywords: NGF; Dorsal root ganglion neurons; Substance P; CGRP; Bradykinin receptors; AD; Alzheimers' disease; BK; bradykinin; B2R; bradykinin 2 receptor; CGRP; calcitonin gene-related peptide; DRG; dorsal root ganglion neurons; Fluo-3 AM; calcium sensitive fluores
Developmental suppression of forebrain trkA receptors and attentional capacities in aging rats: A longitudinal study
Keywords: Development; trkA; Attention; Cholinergic; Aging;
Characterizing nerve growth factor-p75NTR interactions and small molecule inhibition using surface plasmon resonance spectroscopy
Keywords: Nerve growth factor; Surface plasmon resonance; NGF inhibition; p75NTR; TrkA; Biosensor; NGF; nerve growth factor; SPR; surface plasmon resonance; HBS-EP; Hepes-buffered saline with EDTA and surfactant P20; EDTA; ethylenediaminetetraacetic acid; EDC; 1-
Protective effects of matrine on experimental autoimmune encephalomyelitis via regulation of ProNGF and NGF signaling
Keywords: MS/EAE; Oligodendrocytes; NGF; ProNGF; TrkA; p75NTR;
The importance of EHD1 in neurite outgrowth contributing to the functional recovery after spinal cord injury
Keywords: SCI, spinal cord injury; CNS, central nervous system; NGF, Nerve growth factor; EHD1, EPS15 homology domain 1; TrkA, tropomyosin recepter kinase A; EE, early endosome; RE, recycling endosomeEHD1; NGF; TrkA; Neurite outgrowth; SCI
Nerve growth factor & TrkA as novel therapeutic targets in cancer
Keywords: NGF; TrkA; p75NTR; Cancer; Growth; Pain; Gene fusion; Gene rearrangement; Monoclonal antibodies; Microenvironment; Nerves; Therapeutic target
Fine tuning of insulin secretion by release of nerve growth factor from mouse and human islet β-cells
Keywords: NGF; Insulin secretion; Islets of Langerhans; β-cells; trkA; p75NTR; BMI; body mass index; ECL; enhanced chemoluminescence; GDI; GDP-dissociation inhibitor; GTP; guanosine tri-phosphate; HRP; horseradish peroxidase; ICD; intracellular domain; NGF; nerve
Intracellular LINGO-1 negatively regulates Trk neurotrophin receptor signaling
Keywords: LINGO-1; LRRN6a; TrkA; TrkB; TrkC; Linx; Trk; tropomyosin-related kinase; LINGO; leucine-rich repeat Ig-domain containing Nogo-interacting protein; EGFR; epidermal growth factor receptor; NGF; nerve growth factor; BDNF; brain derived neurotrophic factor;
The pruritus- and TH2-associated cytokine IL-31 promotes growth of sensory nerves
Keywords: IL-31; IL-31 receptor α; dorsal root ganglia; atopic dermatitis; nerve growth; cutaneous hyperinnervation; AD; Atopic dermatitis; DRG; Dorsal root ganglia; ERK; Extracellular signal-regulated kinase; IL-31RA; IL-31 receptor α; IPA; Ingenuity pathway ana
Selective and differential interactions of BNN27, a novel C17-spiroepoxy steroid derivative, with TrkA receptors, regulating neuronal survival and differentiation
Keywords: Neurotrophins; Nerve growth factor (NGF); TrkA; Neurodegeneration; Neurotrophin receptors signaling; Neuronal apoptosis; Steroid; STD NMR; Molecular modeling; NGF; nerve growth factor; BDNF; brain-derived neurotrophic factor; NT-3; neurotrophin-3; CYP17;
Chromosomal rearrangements involving the NTRK1 gene in colorectal carcinoma
Keywords: NTRK1; TRKA; Gene rearrangement; Colon cancer;
Perineural invasion in cutaneous squamous cell carcinoma: role of immunohistochemistry, anatomical site, and the high-affinity nerve growth factor receptor TrkA
Keywords: Squamous cell carcinoma; Perineural invasion; Immunohistochemistry; TrkA; Histopathology;
ZDHHC17 promotes axon outgrowth by regulating TrkA-tubulin complex formation
Keywords: DHHC; Asp-His-His-Cys; dpf; days post-fertilization; ERK1/2; extracellular signal-related kinase1/2; hpf; hours post-fertilization; JNK; c-Jun N terminus kinase; MAPK; mitogen-activated protein kinase; NSC; neural stem cell; PAT; palmitoyltransferase; SMN
The deubiquitinating enzyme UBPy/USP8 interacts with TrkA and inhibits neuronal differentiation in PC12 cells
Keywords: TrkA; USP8/UBPy; Deubiquitination; Signaling endosomes; Differentiation; PC12 cells;
Glycation of the high affinity NGF-receptor and RAGE leads to reduced ligand affinity
Keywords: Advanced glycation endproducts (AGEs); Glycation; RAGE; Binding affinity; Neuronal plasticity; TrkA
The effect of mild stress stimulation on the nerve growth factor (NGF) and tyrosine kinase receptor A (TrkA) immunoreactivity in the paraventricular nucleus (PVN) of the hypothalamus and hippocampus in aged vs. adult rats
Keywords: DG; dentate gyrus; FS; forced swim; HL-OF; high-light open-field; HPA; hypothalamic-pituitary-adrenal; NGF; nerve growth factor; PVN; paraventricular nucleus; TrkA; tyrosine kinase receptor A; nerve growth factor (NGF); tyrosine kinase receptor A (Trk
De novo expression of Nav1.7 in injured putative proprioceptive afferents: Multiple tetrodotoxin-sensitive sodium channels are retained in the rat dorsal root after spinal nerve ligation
Keywords: DR; dorsal root; DRG; dorsal root ganglion; dSpN; spinal nerve distal to the ligation site; DTT; dithiothreitol; EDTA; ethylenediaminetetraacetic acid; FA; formaldehyde; GN; gracile nucleus; ISHH; in situ hybridization histochemistry; L5; 5th lumbar; LTMs
Twins with hereditary sensory and autonomic neuropathy type IV with preserved periodontal sensation
Keywords: Congenital insensitivity to pain; TRKA; NTRK1; Mutation; Teeth; Tooth pain
Knockdown of TrkA in cumulus oocyte complexes (COCs) inhibits EGF-induced cumulus expansion by down-regulation of IL-6
Keywords: NGF; nerve growth factor; TrkA; tyrosine receptor kinase A; COCs; cumulus oocyte complexes; GCs; granulosa cells; CCs; cumulus cells; EGF; epidermal growth factor; CEEFs; oocyte-secreted cumulus expansion-enabling factors; Ptgs2; prostaglandin-endoperoxid
Activation of CB1 inhibits NGF-induced sensitization of TRPV1 in adult mouse afferent neurons
Keywords: ACEA; arachidonyl-2â²-chloroethylamide; CB1; cannabinoid receptor 1; CB2; cannabinoid receptor 2; CGRP; calcitonin-gene-related peptide; DRG; dorsal root ganglion; NGF; nerve growth factor; trkA; tyrosine kinase A; TRPV1; transient receptor potential van
The TPM3-NTRK1 rearrangement is a recurring event in colorectal carcinoma and is associated with tumor sensitivity to TRKA kinase inhibition
Keywords: TPM3-NTRK1 rearrangement; TRKA; Kinase inhibitor; NMS-P626; Colorectal cancer;
Type I interferons up-regulate the expression and signalling of p75 NTR/TrkA receptor complex in differentiated human SH-SY5Y neuroblastoma cells
Keywords: Type I interferons; Neurotrophins; p75NTR; TrkA; Signal transduction; Neuronal apoptosis; BDNF; brain-derived neurotrophic factor; CNS; central nervous system; DAPI; 4â²,6-Diamidino-2phenylindole dihydrochloride; EAE; experimental allergic encephalomyeli
c-Src activation through a TrkA and c-Src interaction is essential for cell proliferation and hematological malignancies
Keywords: TrkA; Hematological malignancies; c-Src; PLK-1; Twist-1;
Identification of novel pyrazoloquinazolinecarboxilate analogues to inhibit nerve growth factor in vitro
Keywords: Neurotrophin antagonist; NGF antagonist; PC12 cells; TrkA; Neurotrophin inhibition;
Rit subfamily small GTPases: Regulators in neuronal differentiation and survival
Keywords: CA; constitutively active; cAMP; cyclic adenosine monophosphate; CaM; calmodulin; CCI; controlled cortical impact; CREB; cAMP response element binding protein; CRIB; Cdc42/Rac interactive binding; DA; dopamine; DAT; dopamine transporter; DN; dominant nega
Sympathetic denervation of peri-infarct myocardium requires the p75 neurotrophin receptor
Keywords: BDNF; brain-derived neurotrophic factor; HA; hemagglutinin; 123I-MIBG; iodine-123 meta-iodobenzylguanidine; LAD; left anterior descending coronary artery; MI; myocardial infarction; NGF; nerve growth factor; NE; norepinephrine; p75NTR; p75 neurotrophin re
The role of Src protein in the process formation of PC12 cells induced by the proteasome inhibitor MG-132
Keywords: Cy3; Â a fluorophor cyanin dye; DMEM; Â Dulbecco's Modified Eagle's Medium; DMSO; Â dimethyl-sulfoxyde; EDTA; Â ethylenediaminetetraacetic acid; EGTA; Â ethylene glycol tetraacetic acid; ERK1/2; Â extracellular signal-regulated kinase 1 and 2; H-Ras;