کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8478509 | 1551136 | 2016 | 29 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Intracellular LINGO-1 negatively regulates Trk neurotrophin receptor signaling
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کلمات کلیدی
EGFRNGFTrkBtrkATrkCHL1BDNF - BDNF یا فاکتور نورونزایی مشتقشده از مغز Trk - تراکtropomyosin-related kinase - تریپومیوسین مرتبط با کینازbrain derived neurotrophic factor - عامل مغز استخوان مغز استخوان استnerve growth factor - فاکتور رشد عصبLINX - لینکسLingo - لینگوLINGO-1 - لینگو-1Epidermal growth factor receptor - گیرنده فاکتور رشد اپیدرمال
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
Neurotrophins, essential regulators of many aspects of neuronal differentiation and function, signal via four receptors, p75, TrkA, TrkB and TrkC. The three Trk paralogs are members of the LIG superfamily of membrane proteins, which share extracellular domains consisting of leucine-rich repeat and C2 Ig domains. Another LIG protein, LINGO-1 has been reported to bind and influence signaling of p75 as well as TrkA, TrkB and TrkC. Here we examine the manner in which LINGO-1 influences the function of TrkA, TrkB and TrkC. We report that Trk activation promotes Trk association with LINGO-1, and that this association promotes Trk degradation by a lysosomal mechanism. This mechanism resembles the mechanism by which another LIG protein, LRIG1, promotes lysosomal degradation of receptor tyrosine kinases such as the EGF receptor. We present evidence indicating that the Trk/LINGO-1 interaction occurs, in part, within recycling endosomes. We show that a mutant form of LINGO-1, with much of the extracellular domain deleted, has the capacity to enhance TrkA signaling in PC12 cells, possibly by acting as an inhibitor of Trk down-regulation by full length LINGO-1. We propose that LINGO-1 functions as a negative feedback regulator of signaling by cognate receptor tyrosine kinases including TrkA, TrkB and TrkC.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular and Cellular Neuroscience - Volume 70, January 2016, Pages 1-10
Journal: Molecular and Cellular Neuroscience - Volume 70, January 2016, Pages 1-10
نویسندگان
James S. Meabon, Rian de Laat, Katsuaki Ieguchi, Dmitry Serbzhinsky, Mark P. Hudson, B. Russel Huber, Jesse C. Wiley, Mark Bothwell,