Proximal tubule proteins are significantly elevated in bladder urine of patients with ureteropelvic junction obstruction and may represent novel biomarkers: A pilot study

Targeted identification of reliable, noninvasive biomarkers of renal injury is critical to aid in diagnosing patients at risk, guiding therapeutic decisions and monitoring treatment efficacy. Proximal tubule brush border proteins are reliably detected in the urine of obstructed patients and may be more effective at predicting UPJO.429Figure. Box plot of known biomarkers (KIM-1 (A) and NGAL (B)) compared with novel proximal tubule biomarkers (CD10 (C), CD13 (D) and CD26 (E)). Data expressed in relative units.*p < 0.05; **p < 0.01.