Neuropsychological functioning related to specific characteristics of nocturnal enuresis

For children with MNE and associated NP, a high comorbidity with the predominantly inattentive presentation of ADHD was demonstrated. Children experienced problems with daytime functioning in relation to their wetting problem at night. According to the teachers, a low maximum voided volume was associated with more attention problems, and a high number of nights with NP was associated with more behaviour-regulation problems. Although comorbidity is still the appropriate word to use, the observation favours a more complex pathogenesis of enuresis with a common pathway in the central nervous system, including: neurotransmitters, influencing neuropsychological functioning as well as sleep, circadian rhythm of diuresis and bladder function control. Table. Enuresis parameters, pairwise correlations with ADHD-inattentive symptoms and executive functioning.Psychological domainMeasurementMVVNumber of wet nightsNumber of nights with NPADHD inattentive symptomsCANTAB Rapid Visual information Processing0.219−0.017−0.206Test of Everyday Attention for Children Score Double Task0.119−0.234−0.080 Code Transmission−0.241−0.160−0.047DBDRS inattentive subscale Parents−0.1780.072−0.135 Teachers−0.585*0.2290.295Executive functioningCANTAB Spatial recognition memory−0.0800.046−0.071 Spatial span−0.085−0.0740.002 Intra/extra dimensional set shift0.188−0.380−0.280 Stockings of Cambridge−0.123−0.241−0.073 Stop signal taska−0.062−0.2050.251BRIEF (total behaviour regulation index) Parents0.1190.1720.026 Teachers0.0850.0770.663*ADHD, Attention Deficit Hyperactivity Disorder; BRIEF, Behavior Rating Inventory of Executive Function; CANTAB, Cambridge Neuropsychological Test Automated Battery; DBDRS, Disruptive Behavior Disorder Rating Scale; MVV, Maximum Voided Volume; NP, Nocturnal Polyuria.* P < 0.05.araw scores.