Can the effect of adhesion barriers and/or intravesical balloon inflation improve bladder autoaugmentation outcomes in a rabbit model?

Bladder autoaugmentation in a rabbit model, followed by intravesical balloon inflation offers improvement in bladder capacity and compliance. The use of sprayable adhesion barrier hydrogel technology may facilitate tissue healing and result in it being easier to maintain the success achieved by surgery when only supported with an intravesical balloon.Table. Bladder capacity and compliance values of all groups: pre-operative, postoperative and 90 days after surgery.GroupsCapacity on day 0 (before reduction) Mean ± SD (ml)Capacity on day 0 (after reduction) Mean ± SD (ml)Compliance on day 0 (after reduction) Mean ± SD (ml/cm H2O)Capacity on day 90, Mean ± SD (ml)Compliance on day 90, Mean ± SD (ml/cm H2O)Δ Capacity Mean ± SDΔ Compliance Mean ± SDGroup 1 (sham)23.8 ± 2.123.8 ± 2.113.5 ± 0.923.6 ± 2.013.1 ± 1.00.2 ± 0.10.4 ± 0.3Group 2 (control)24.4 ± 1.918.6 ± 1.93.6 ± 0.218.9 ± 1.93.9 ± 0.20.3 ± 0.10.3 ± 0.1Group 3 (IVBA)25.3 ± 1.219.1 ± 0.73.9 ± 0.323.4 ± 0.913.0 ± 0.34.6 ± 0.6*9.1 ± 0.2*Group 4 (AB)24.7 ± 0.818.4 ± 1.43.3 ± 0.518.9 ± 1.33.9 ± 0.50.4 ± 0.20.6 ± 0.1Group 5 (IVBA + AB)24.1 ± 1.318.1 ± 0.83.4 ± 0.222.8 ± 1.012.5 ± 0.44.6 ± 0.5*9.2 ± 0.2**P < 0.05.AB, adhesion barrier; IVBA, intravesical balloon application.The mean increase in bladder capacity and compliance between day 0 (after reduction) and day 90.