کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4162919 1274294 2011 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Randomized comparison of long-term desmopressin and alarm treatment for bedwetting
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پریناتولوژی (پزشکی مادر و جنین)، طب اطفال و بهداشت کودک
پیش نمایش صفحه اول مقاله
Randomized comparison of long-term desmopressin and alarm treatment for bedwetting
چکیده انگلیسی

ObjectiveTo compare the efficacy of long-term primary nocturnal enuresis (PNE) treatment using desmopressin versus enuresis alarm.Materials and methodsA 6-month randomized trial was performed with patients from 29 enuresis clinics: 251 patients ≥5 years in age with severe PNE (mean 5.5–5.6 wet nights/week) were randomized to desmopressin (0.2–0.4 mg daily) or alarm. Efficacy was assessed by percentage reduction in mean number of wet nights/week; patients achieving dryness, mean initial duration of sleep and compliance were evaluated. Efficacy analyses were performed using the intent-to-treat population (all patients) and excluding patients who withdrew; 12-month follow-up data were collected.ResultsData could not be evaluated for the 32% of alarm patients and 7% of desmopressin patients who withdrew early. In intent-to-treat analyses, a similar proportion of patients across groups showed a ≥50% reduction in wet nights/week (desmopressin: 37.5%, alarm: 32.2%) and achieved dryness (desmopressin: 32%, alarm: 37%). Compliance was higher with desmopressin: 95–98% of patients took >75% of tablets; 50–78% used alarm >75% of nights. Initial sleep duration was 1.02 h longer at the end of treatment with desmopressin (95% CI: 0.045, 1.99).ConclusionDesmopressin and alarm demonstrated comparable efficacy in the treatment of PNE. Withdrawal from the alarm group was high, indicating the importance of considering family motivation before selecting treatment, for optimal outcome.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pediatric Urology - Volume 7, Issue 1, February 2011, Pages 21–29
نویسندگان
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