Rate of Weight Gain and Cardiometabolic Abnormalities in Children and Adolescents

Compared with weight measured concurrently, the rate of weight gain in risperidone-treated children accounts for an equal or larger share of the variance in certain cardiometabolic outcomes (eg, HDL cholesterol [ΔR2 = 8% vs ΔR2 = 11%] and high-sensitivity C-reactive protein [ΔR2 = 5% vs ΔR2 = 9%]) and may serve as a treatment target.