کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4167398 1607516 2009 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A New Cystic Fibrosis Newborn Screening Algorithm: IRT/IRT1↑/DNA
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پریناتولوژی (پزشکی مادر و جنین)، طب اطفال و بهداشت کودک
پیش نمایش صفحه اول مقاله
A New Cystic Fibrosis Newborn Screening Algorithm: IRT/IRT1↑/DNA
چکیده انگلیسی

ObjectiveTo evaluate an immunoreactive trypsinogen (IRT) IRT/IRT1↑/DNA algorithm, aimed at improving sensitivity while decreasing cystic fibrosis (CF) carrier identification.Study designNew technologies allow the measurement of the second IRT level solely in infants with an elevated first IRT level. Specimens with an elevated second IRT level undergo mutation analysis. We tested the projected efficacy with retrospective data from Colorado.ResultsAll known infants with CF would have been identified with our proposed IRT cutoff points, and 3 would have been missed with our mutation panel. Two of 3 missed cases would have been identified by using a failsafe method (IRT >99.9th percentile), yielding a sensitivity rate of 99.7% (95% CI, 98.4-99.9). Estimated reduction in carrier detection was 80% compared with IRT/DNA.ConclusionIRT/IRT1↑/DNA appears to improve cystic fibrosis newborn screen sensitivity while decreasing carrier identification, providing an alternative to IRT/IRT in states that obtain 2 blood spots.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Journal of Pediatrics - Volume 155, Issue 5, November 2009, Pages 618–622
نویسندگان
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