کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4175070 1276168 2013 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Nasopharyngeal Carriage and Antimicrobial Susceptibility Pattern of Streptococcus Pneumoniae among Pediatric Outpatients at Gondar University Hospital, North West Ethiopia
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پریناتولوژی (پزشکی مادر و جنین)، طب اطفال و بهداشت کودک
پیش نمایش صفحه اول مقاله
Nasopharyngeal Carriage and Antimicrobial Susceptibility Pattern of Streptococcus Pneumoniae among Pediatric Outpatients at Gondar University Hospital, North West Ethiopia
چکیده انگلیسی

BackgroundPneumonia caused by Streptococcus pneumoniae is the leading cause of death among children in Ethiopia. S. pneumoniae nasopharyngeal carriage can result in endogenous infections and bacterial spread in the community. S. pneumoniae drug resistance is rapidly increasing worldwide. The aim of the study was to assess the nasopharyngeal carriage and antimicrobial susceptibility pattern of S. pneumoniae among pediatric outpatients.MethodsA cross-sectional study was conducted on children aged ≤10 years from February to May of 2012. Data on potential risk factors were gathered using an interview-based questionnaire. Nasopharyngeal specimens were collected with a sterile plastic cotton tip swab. Bacteria were characterized by colony appearance, Gram staining, and optochin susceptibility and bile solubility tests. An antimicrobial susceptibility test was performed using the disk diffusion method. A logistic regression analysis was used to examine the possible risk factors. All tests with p value less than 0.05 were considered statistically significant.ResultsOf the 234 children screened, 41.03% carried S. pneumoniae. Age-related downward trend for S. pneumoniae carriages (50.9% in <3-year-olds, 40.7% in 3- to 5-year-olds, 40.0% in 5- to <8-year-olds, and 33.3% in 8- to 10-year-olds) were observed. Children living with siblings < 5 years old (p = 0.003) and in a house having one room (p = 0.004) were associated with higher S. pneumoniae carriage. S. pneumoniae showed 33.2% resistance to erythromycin and tetracycline, 29.2% to cotrimoxazole, 14.6% to chloramphenicol and ciprofloxacin, and 10.4% to penicillin.ConclusionThe S. pneumoniae carriage rate was higher among younger children. High antimicrobial resistance of S. pneumoniae against erythromycin, tetracycline, and cotrimoxazole was observed. Being in the young age group and living with younger children are risk factors for pneumococcal carriage.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pediatrics & Neonatology - Volume 54, Issue 5, October 2013, Pages 315–321
نویسندگان
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