کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4176297 1607962 2006 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Live Attenuated Human Rotavirus Vaccine, Rotarix™
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پریناتولوژی (پزشکی مادر و جنین)، طب اطفال و بهداشت کودک
پیش نمایش صفحه اول مقاله
Live Attenuated Human Rotavirus Vaccine, Rotarix™
چکیده انگلیسی

Rotavirus infections are the leading cause of severe gastroenteritis in young children worldwide. Recently two new rotavirus vaccines have entered the world market. This review provides a summary of the rationale, development, and evaluation of one of these vaccines, Rotarix*. Rotarix* is a live oral rotavirus vaccine developed from a single protective human strain following multiple passages in tissue culture to attenuate the strain. The vaccine is administered as two oral doses at approximately 2 and 4 months of age. Large safety and efficacy trials have shown the vaccine is safe, not associated with intussusception, and effective against the most common circulating human serotypes. Efficacy against severe rotavirus gastroenteritis and hospitalization have ranged from 85 to 100 percent.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Pediatric Infectious Diseases - Volume 17, Issue 4, October 2006, Pages 188–194
نویسندگان
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