کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4186116 1608177 2012 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Early and late onset, first-episode, treatment-naive depression: same clinical symptoms, different regional neural activities
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی روانپزشکی و بهداشت روانی
پیش نمایش صفحه اول مقاله
Early and late onset, first-episode, treatment-naive depression: same clinical symptoms, different regional neural activities
چکیده انگلیسی

BackgroundPatients with early onset depression (EOD) and late onset depression (LOD) have distinctive risk factors and clinical pictures. Using regional homogeneity (ReHo) approach, we were to test the hypothesis of the different abnormal neural activity between patients with EOD or LOD.MethodsFifteen patients with EOD, 15 patients with LOD, 15 young healthy subjects (HS) and 15 old HS participated in the study. ReHo approach was employed to analyze the scans.ResultsANOVA analysis revealed widespread differences in ReHo values among the four groups throughout frontal, parietal, temporal, occipital cortex, cerebellum and limbic regions. Compared to LOD group, EOD group had higher ReHo in right precuneus (PCu) and bilateral superior frontal gyrus, and lower ReHo in left superior temporal gyrus. Compared to young HS, lower ReHo in left parahippocampal gyrus and higher ReHo in left fusiform gyrus and bilateral superior frontal gyrus were seen in EOD group; in contrast, in LOD group, lower ReHo in right PCu and higher ReHo in left superior temporal gyrus and left Crus I of the cerebellum were observed. Further ROC analysis suggested that the mean ReHo values in right PCu and bilateral superior frontal gyrus could serve as markers to identify patients with EOD from individuals with LOD.LimitationThe large age gap may limit the translational value of our findings.ConclusionsPatients with EOD and those with LOD have abnormal neural activities in different brain regions, although the two groups share the same symptoms.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Affective Disorders - Volume 143, Issues 1–3, 20 December 2012, Pages 56–63
نویسندگان
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