کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4186658 1608193 2010 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Oxidative stress and brain glutamate-mediated excitability in depressed patients
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی روانپزشکی و بهداشت روانی
پیش نمایش صفحه اول مقاله
Oxidative stress and brain glutamate-mediated excitability in depressed patients
چکیده انگلیسی

BackgroundSeveral neuropsychiatric pathologies have been recently linked to oxidative stress. In this study, we investigated the relationship between depression, markers of oxidative stress and neurotransmission, as expressed by sensory cortex excitability.MethodsSerum levels of oxidative stress markers and somatosensory magnetic fields, evoked by external galvanic stimulation, were measured in 13 depressed patients and 13 controls.ResultsDepressives had higher levels of total and free copper than controls and lower levels of transferrin. They also showed lower sensory cortex excitability, which correlated with copper levels in controls, but not in patients. Transferrin correlated with sensory cortex excitability in both patients and controls, although in opposite ways. Copper level results associated with the patients' clinical status.LimitationsSmall sample size and possible sampling bias in patient selection.ConclusionsPro-oxidant agents appear to affect neuronal excitability and clinical state of depressed patients, as free copper excess alters their cortical glutamatergic neurotransmission.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Affective Disorders - Volume 127, Issues 1–3, December 2010, Pages 321–325
نویسندگان
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