کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4186792 1608194 2010 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Risk factors of treatment resistance in major depression: Association with bipolarity
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی روانپزشکی و بهداشت روانی
پیش نمایش صفحه اول مقاله
Risk factors of treatment resistance in major depression: Association with bipolarity
چکیده انگلیسی

BackgroundAn undiagnosed and therefore inadequately treated bipolarity may be an important cause of drug resistance in depression diagnosed as unipolar. The study aimed to detect clinical and demographic characteristics, with a special interest in bipolarity features which could be risk factors for treatment resistance in unipolar depression.MethodOne-thousand and fifty-one patients recruited from 150 outpatient psychiatric clinics and fulfilling DSM-IV criteria for major depressive episodes, single or recurrent, were studied. Among them, 569 patients with treatment-resistant depression (TR) were compared with 482 patients with non-treatment-resistant depression (NTR). All patients were assessed using the structured demographic and clinical data interviews, Mood Disorder Questionnaire (MDQ) and Hypomania Checklist (HCL-32).ResultsIndependent risk factors of treatment resistance were: scoring 6 or higher on MDQ, scoring 14 or higher in HCL-32, age at first onset ≤ 20 years, more than three previous depressive episodes, and lack of remission or partial remission after the previous depressive episode.LimitationA retrospective assessment of treatment resistance.ConclusionsBipolarity features as assessed by MDQ and HCL-32 were identified as significant factors of treatment resistance. Some other clinical variables connected with treatment resistance may be also be associated with bipolarity features.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Affective Disorders - Volume 126, Issues 1–2, October 2010, Pages 268–271
نویسندگان
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