کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4186909 1608199 2010 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Severe affective and behavioral dysregulation in youth is associated with increased serum TSH
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی روانپزشکی و بهداشت روانی
پیش نمایش صفحه اول مقاله
Severe affective and behavioral dysregulation in youth is associated with increased serum TSH
چکیده انگلیسی

BackgroundThe relationship of bipolar disorder (BD) and altered thyroid function is increasingly recognized. Recently, a behavioral phenotype of co-occurring deviance on the Anxious/Depressed (A/D), Attention Problems (AP), and Aggressive Behavior (AB) syndrome scales has been identified as the Child Behavior Checklist Dysregulation Profile (CBCL-DP), which itself has been linked to BD. This study tested for differences in thyroid function within a sample of n = 114 psychiatric children and adolescents with and without the CBCL-DP.MethodA CBCL-DP score was generated based on the composite of the crucial CBCL syndrome scales (A/D, AP, AB). Participants with a CBCL-DP score ≥ 2.5 SDs above average constituted the CBCL-DP subgroup (n = 53). Those with CBCL-DP scores of 1 SD or less above average percentile were regarded as controls (n = 61). Groups were compared regarding serum levels of TSH, fT3 and fT4.ResultsIn participants showing the CBCL-DP, basal serum TSH was elevated compared to controls. More CBCL-DP subjects than controls showed subclinical hypothyroidism. No differences were observed for serum fT3 and fT4 levels.ConclusionsThis is the first study to demonstrate associations between CBCL-DP and subclinical hypothyroidism. Future research should address the long-term outcome of CBCL-DP with coexisting hypothyroidism, the potential benefits of supplementation with thyroid hormone, and the association between severe dysregulation and the bipolar spectrum.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Affective Disorders - Volume 121, Issues 1–2, February 2010, Pages 184–188
نویسندگان
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