Gastric dysmotility in patients with major depression

BackgroundDepressed patients frequently complain about vegetative symptoms. The aim of the present study was to evaluate gastric electrical activity in patients suffering from major depression in relation to their symptoms.MethodsElectrogastrography (EGG) was performed before and after a test meal ingestion in 21 patients suffering from major depression and control subjects. A structured interview was used to assess the severity of clinical as well as abdominal symptoms.ResultsPatients presented with significantly elevated proportions of tachygastria. Significant differences were found for the parameter arrhythmia, the coefficient of dominant frequency and slow wave after the test meal ingestion. A positive correlation was found between tachygastria and ANS score as well as tachygastria and the item “sweating”.LimitationsFurther studies are warranted to include more patients and to investigate interaction with specific antidepressive drugs.DiscussionThis is the first study demonstrating an increased amount of tachygastria in patients suffering from major depression which might be caused by increased sympathetic modulation. The correlation of tachygastria with the amount of gastric symptoms underlines the clinical significance of this finding.