Trityl chloride as an efficient organic catalyst for the synthesis of 1-amidoalkyl-2-naphtols in neutral media at room temperature

A highly efficient and simple procedure for the preparation of 1-amidoalkyl-2-naphthols via one-pot three-component condensation reaction of 2-naphthol, arylaldehydes and acetonitrile (Ritter type reaction) in the presence of catalytic amount of trityl chloride at room temperature is described. The reactions proceed in high yields and in relatively short reaction times.

Figure optionsDownload high-quality image (27 K)Download as PowerPoint slideResearch highlights▶ Introducing an efficient new catalyst for synthesis of 1-amidoalkyl-2-naphthols. ▶ The synthesis of bis(1-amidoalkyl-2-naphthol)s. ▶ The use of trityl chloride as a non-acidic organic catalyst. ▶ Performing the reaction at room temperature. ▶ Generality of the method, high yields and short reaction times.