کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4201048 1279387 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effect of Liuweidihuang pill and Jinkuishenqi pill on inhibition of spontaneous breast carcinoma growth in mice
ترجمه فارسی عنوان
اثر قرص لیوئیدیهووان و قرص جینکویچنکو بر مهار رشد کارسینومای خودبخودی در موش سوری
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی سیاست های بهداشت و سلامت عمومی
چکیده انگلیسی

ObjectiveTo investigate the preventing and treating action of Liuweidihuang pill (LP) and Jinkuishenqi pill (JP) on spontaneous breast carcinoma in mice.MethodsA model of spontaneous breast carcinoma was derived from 11.5-month-old female Kunming breeding mice following the delivery of several litters. The mice were randomly divided into five groups: model control group (C), Liuweidihuang pill high-dose group (LH; 4.6 g
• kg−1
• d−1), Liuweidihuang pill low-dose group (LL; 2.3 g
• kg−1
• d−1), Jinkuishenqi pill high-dose group (JH; 4.6 g
• kg−1
• d−1) and Jinkuishenqi pill low-dose group (JL; 2.3 g
• kg−1
• d−1). Cancer tissue volume was measured by water immersion. Histopathology was analyzed by hematoxylin and eosin staining. Vascular endothelial growth factor (VEGF), extracellular signal-regulated kinase (ERK) and cyclin D1 protein expression in cancer tissue was assayed by western blotting.ResultsCompared with the control group, cancer tissue volume and weight were lower in the LP and JP groups, and survival time was longer. The expression of VEGF, ERK and Cyclin D1 were inhibited in the LP and JP groups (P < 0.05), and cell differentiation was increased. Tumor weights and volumes and VEGF, ERK and Cyclin D1 expression in LL or LH were significantly lower than in JL and JH (P < 0.01).ConclusionBoth LP and JP could restrain cancer growth and promote cancer cell differentiation; moreover, LP was more effective than JP The likely mechanism of action was via inhibition of VEGF, ERK and cyclin D1.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Traditional Chinese Medicine - Volume 35, Issue 4, 15 August 2015, Pages 453–459
نویسندگان
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