کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4207936 1280423 2016 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The impact of Cystic Fibrosis Transmembrane Regulator Disruption on cardiac function and stress response
ترجمه فارسی عنوان
تاثیر فاکتور تنظیم کننده ترانسمیتری فیبروز کیستیک بر عملکرد قلبی و پاسخ استرس
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی ریوی و تنفسی
چکیده انگلیسی

BackgroundAltered cardiac function has been observed in cystic fibrosis transmembrane regulator (CFTR) knockout mice. However, whether this alteration is a direct effect of CFTR disruption in the heart, or is secondary due to systemic loss of CFTR, remains to be elucidated.MethodsCardiac function of mice with muscle-specific or global knockout of CFTR was evaluated at baseline and under β-stimulation by MRI in vivo. Myocyte contractility and Ca2 + transients were measured in vitro.ResultsBoth CFTR knockout models showed increased twist and torsion at baseline. Response to β-stimulation was unaltered in muscle-specific CFTR knockout mice and was slightly decreased in global CFTR knockout mice. Aortic diameter was also decreased in both mouse models. No difference was observed in myocyte contractility and Ca2 + transients.ConclusionsCFTR disruption leads to increased myocardial contractility at baseline, which may trigger untoward myocardial remodeling in CF patients that is independent of lung diseases.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Cystic Fibrosis - Volume 15, Issue 1, January 2016, Pages 34–42
نویسندگان
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