کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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4208092 | 1280427 | 2015 | 6 صفحه PDF | دانلود رایگان |
BackgroundPrevious studies of CF treatments have shown suboptimal adherence, though little has been reported regarding adherence patterns to ivacaftor. Electronic monitoring (EM) of adherence is considered a gold standard of measurement.MethodsAdherence rates by EM were prospectively obtained and patterns over time were analyzed. EM-derived adherence rates were compared to pharmacy refill history and self-report.Results12 subjects (age 6–48 years; CFTR-G551D mutation) previously prescribed ivacaftor were monitored for a mean of 118 days. Overall adherence by EM was 61%(SD = 28%) and decreased over time. Median duration between doses was 16.9 hours (IQR 13.9–24.1 hours) and increased over time. There was no correlation between EM-derived adherence and either refill history (84%, r = 0.26, p = 0.42) or self-report (100%, r = 0.40, p = 0.22).ConclusionsDespite the promising nature of ivacaftor, our data suggest adherence rates are suboptimal and comparable to other prescribed CF therapies, and more commonly used assessments of adherence may be unreliable.
Journal: Journal of Cystic Fibrosis - Volume 14, Issue 5, September 2015, Pages 621–626