کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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4208330 | 1280437 | 2014 | 4 صفحه PDF | دانلود رایگان |

BackgroundMucins are excellent candidates for contributing to the presence of meconium ileus (MI) in cystic fibrosis (CF) due to their extensive genetic variation and known function in intestinal physiology. The length of variants in mucin central repetitive regions has not been explored as “risk” factors for MI in CF.MethodsWe investigated the length polymorphisms in the central repetitive regions of MUC1, MUC2, and MUC5AC by Southern blot and tested for association with MI in CF subjects.ResultsNo significant associations were found for the allele sizes of any of the genes with respect to the prevalence of MI (p values = 0.33, 0.16, and 0.71 for MUC1, MUC2, and MUC5AC, respectively).ConclusionsThe genetic length variants in the central repetitive region of three MUC genes studied are not associated with MI in subjects with CF.
Journal: Journal of Cystic Fibrosis - Volume 13, Issue 6, December 2014, Pages 613–616