کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4208341 1280437 2014 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Lung clearance index during hospital admission in school-age children with cystic fibrosis
ترجمه فارسی عنوان
شاخص ریوی در هنگام بستری شدن در بیمارستان های مدرسه ای با فیبروز کیستیک
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی ریوی و تنفسی
چکیده انگلیسی

BackgroundThere is currently limited information regarding lung clearance index (LCI) and its response to treatment of pulmonary exacerbations in CF. We aimed to examine the utility of LCI for assessing short term clinical response to IV antibiotic therapy in school-age children with CF.MethodsSubjects experiencing exacerbations and hospitalised for IV antibiotics performed both multiple breath nitrogen washout (MBNW) and spirometry on admission to hospital and prior to discharge.Results27 patients (aged 6–20 years) had paired data for MBNW and spirometry. Mean LCI reduced from 12.18 to 11.65 (4.4%) by time of discharge and FEV1z-score improved from − 3.05 to − 2.86 (6.2%). Overall, LCI improved in n = 15 (55%) patients compared with n = 18 (67%) where FEV1 improved.ConclusionsIn summary, these findings do not support the use of LCI (or indeed, FEV1) to gauge the short term clinical response to IV antibiotic therapy in school-age children with cystic fibrosis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Cystic Fibrosis - Volume 13, Issue 6, December 2014, Pages 687–691
نویسندگان
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