کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4208364 1280438 2014 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Predictive values of antibodies against Pseudomonas aeruginosa in patients with cystic fibrosis one year after early eradication treatment
ترجمه فارسی عنوان
مقادیر پیش بینی کننده آنتیبادی علیه سودوموناس آئروژینوزا در بیماران مبتلا به فیبروز کیستیک یک سال پس از درمان ریشه کنی زودهنگام
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی ریوی و تنفسی
چکیده انگلیسی

BackgroundPatient dependent parameters to predict the long-term success of early eradication treatment of Pseudomonas aeruginosa have not yet been defined. For this purpose we assessed serum antibodies against P. aeruginosa in CF patients after early eradication treatment.MethodsRetrospective analyses of all consecutive patients with first P. aeruginosa detection 2005 to 2008. Absence of P. aeruginosa in the third year was defined as successful long-term eradication. Main outcome was to determine the predictive value of P. aeruginosa antibody results one year after initiation of early eradication treatment using antibodies against alkaline protease, elastase, and exotoxin A with regard to long-term success of eradication treatment.ResultsAntibodies against P. aeruginosa correlated well with success of eradication; positive and negative predictive values after one year were 75% and 82% respectively. The incidence of new detection of P. aeruginosa was 8.5%. Long-term eradication was successful in 32 of 53 patients (60%).ConclusionsDetermination of serum antibodies against P. aeruginosa one year after first detection of P. aeruginosa and early eradication treatment can predict success of long-term eradication.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Cystic Fibrosis - Volume 13, Issue 5, September 2014, Pages 534–541
نویسندگان
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