کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4209267 1280475 2009 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A safe protocol for rapid desensitization in patients with cystic fibrosis and antibiotic hypersensitivity
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی ریوی و تنفسی
پیش نمایش صفحه اول مقاله
A safe protocol for rapid desensitization in patients with cystic fibrosis and antibiotic hypersensitivity
چکیده انگلیسی

BackgroundCF patients often demonstrate hypersensitivity to one or multiple antibiotics due to frequent and repeated exposures. Attempts at antibiotic desensitization in this population are historically complicated by higher reaction rates, failure to complete the procedure and consequent withholding of first-line therapy. This study evaluates the outcomes of a rapid desensitization protocol developed at our institution.MethodsWe retrospectively reviewed the medical records of 15 patients undergoing 52 rapid antibiotic desensitizations at Brigham and Women's Hospital and Children's Hospital Boston utilizing our protocol.ResultsMean FEV1 % predicted was 44.1 (SD 16.5), with two patients at <30% and one patient desensitized during bilateral lung transplantation. Adverse reactions during desensitization occurred in 13.4%, and most were mild. 100% of patients completed the protocol and ultimately tolerated subsequent full-strength antibiotic courses.ConclusionsCF patients with antibiotic hypersensitivity can safely receive first-line antibiotics via our rapid desensitization protocol, including those with severe obstructive lung disease.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Cystic Fibrosis - Volume 8, Issue 6, December 2009, Pages 418–424
نویسندگان
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